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how long does it take for advantage multi to work

One dog showed signs of treatment site irritation after application. The chemical name for moxidectin is [6R, 23E, 25S(E)]-5-O-Demethyl-28-deoxy-25-(1,3-dimethyl-1-butenyl)- 6,28-epoxy-23-(methoxyimino) milbemycin B. Twist the cap to break the seal, and then remove the cap from the tube. If contact with eyes occurs hold eyelids open and flush with copious amounts of water for 15 minutes. As specified in the following table, administer the entire contents of the Advantage Multi® for Dogs tube that correctly corresponds with the body weight of the dog. (Advantage Multi) Common Drug Name Imidacloprid plus moxidectin Common Brand Names Advantage Multi for Cats Advantage Multi for Dogs Note: Advantage Multi for Cats (in the 0.4 mL size only) has now been approved by FDA for some uses in ferrets. Advantage topicals will not protect your pet from ticks-- K9 Advantix for Dogs, however, does protect against ticks. The other thing that should concern everyone is that Advocate/Advantage-Multi is labelled for use once a month — and yet all these vets are … Do not allow the dog to lick any of the application sites for30 minutes. How do I store and dispose of Advantage® II? Turn the cap around and place the other end of the cap back on the tube. Yes. Safety Study in Puppies: Advantage Multi for Dogs was applied topically at 1, 3 and 5X the recommended dose to 7-week-old Beagle puppies once every 2 weeks for 6 treatments on days 0, 14, 28, 42, 56, and 70. You need to use it on every animal you keep in the house. You can easily place an order on our website in under 5 minutes. Box 390 Shawnee Mission, Kansas 66201 U.S.A. Information about how quickly a medication starts to work is easily available by reading the product label, visiting the manufacturer’s website, or by talking to your veterinarian. Bayer, the Bayer Cross and Advantage Multi are registered trademarks of Bayer. Advantage Multi is applied to your dog’s skin once a month. Turn the cap over and push the other end of cap onto the tip of the tube. Advantage® II for dogs kills fleas on dogs within 12 hours of application. Bayer HealthCare LLC Do not use this product (containing 2.5% moxidectin) on cats. Advantage Multi for Dogs is indicated for the prevention of heartworm disease caused by Dirofilaria immitis.Advantage Multi for Dogs kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis). Prevents and treats: Kills fleas at multiple life stages. Laboratory Effectiveness Studies: One dog in a laboratory effectiveness study experienced weakness, depression, and unsteadiness between 6 and 9 days after application with Advantage Multi for Dogs. For a copy of the Material Safety Data Sheet (MSDS) or to report adverse reactions call Bayer Veterinary Services at 1-800-422-9874. This is true even after baths or swimming, as the Advantage products are waterproof. For dogs weighing 20 lbs. Dermal Safety Study in Ivermectin-Sensitive Collies:Advantage Multi for Dogs was administered topically at 3 and 5X the recommended dose every 28 days for 3 treatments to Collies which had been pre-screened for avermectin sensitivity. Before applying, check the weight range and minimum age on the package to choose the appropriate product for your dog. Pyriproxyfen is an … The dog should be standing for application. Well, I got the Advantage for them, and the flea pill, and they had them about 5 days ago. Advantage is a spot-on solution that is easy to apply and kills fleas on contact, so fleas don’t have to bite to die. (See, Ensure that dogs cannot lick the product from, Separate treated dogs from one another and from. However, more frequent swimming may keep the product from working the full 30 days. Dogs 55+ pounds – 4.0 ml. Yes! Have person sip a glass of water if able to swallow. The following clinical observations also occurred in laboratory effectiveness studies following application with Advantage Multi for Dogs and may be directly attributed to the drug or may be secondary to the intestinal parasite burden or other underlying conditions in the dogs: diarrhea, bloody stools, vomiting, anorexia, lethargy, coughing, ocular discharge and nasal discharge. CAUTION: Federal (U.S.A.) law restricts Advantage Multi® for Dogs to use by or on the order of a licensed veterinarian. Flea Treatment: For the treatment of flea infestations, Advantage Multi for Dogs should be administered at one-month intervals. The safe use of Advantage Multi for Dogs has not been established in puppies and dogs less than 7 weeks of age or less than 3 lbs. 1 card / 6 doses per card (0.8 mL tubes) — 08891446. Cats 10+ pounds – 0.8 ml. Advantage Multi® (imidaclopid + moxidectin) Discover how Advantage Multi® has an innovative transdermal formula with imidacloprid + moxidectin for monthly flea protection. Pyriproxyfen is an insect growth regulator (IGR) that kills flea eggs and larvae. Place the tip of the tube on the skin between your dog's shoulder blades and gently squeeze to expel the solution on their skin. Never place unused product down any indoor or outdoor drain. Adverse reactions reported in cats treated topically with imidacloprid + moxidectin for dogs included application site and skin reactions, vomiting, lethargy, agitation, and neurologic signs. In households with multiple pets, keep each treated dog separated from other treated dogs and other pets for 30 minutes after application to prevent licking the application sites. The tablet is beef flavored so your dog should readily accept it as a treat. Part the hair on the back of the dog between the shoulder blades until the skin is visible. To further break down the Advantage … (See CONTRAINDICATIONS.). Advantage Multi ® for Cats and Dogs does have an expiration date that can be found on the bottom edge of the package. Kills fleas through contact, so fleas don't have to bite your dog to die. Some flea and tick medications take quite a long time to become effective, but others can bring your dog or cat relief within just a couple of hours! Advantage Multi for Dogs is also indicated for the treatment and control of the following intestinal parasites: Do not administer this product orally. Advantage Multi® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. Top questions about Advantage® II for Dogs, Unlike chewable forms of flea prevention, Advantage, There is no expiration date required on the packaging by the EPA for Advantage. Unlike chewable forms of flea prevention, Advantage® II is applied topically and kills flea eggs, flea larvae and adult fleas through contact with your treated dog. CAUTION: Federal (U.S.A.) law restricts Advantage Multi ® for Dogs to use by or on the order of a licensed veterinarian.. However, reinfestation from the emergence of pre-existing pupae in the environment may continue to occur for six weeks or longer … More on Flea Treatments Bayer HealthCare LLC Animal Health Division. How long does Advantage® II for dogs last? Yes! Adverse events reported in dogs topically treated with imidacloprid + moxidectin for dogs included: vomiting, diarrhea, bloody diarrhea, salivation, poor appetite, lethargy, weakness, restlessness, agitation, disorientation, ataxia, muscle tremors, seizures, panting, labored breathing, acute pulmonary edema, hives, rash, swollen face and ears, pruritus, erythema, alopecia, hot spots, local discomfort, and discoloration of the hair at the application site. I totally agree with DLB, Advantage, if used properly (follow instructions), takes effect inside the first 48 hours. Two puppies each in the 1X, 3X, and 5X groups had decreased appetites within 24 hours post-dosing. Unlike chewable forms of flea prevention, Advantage® II is applied topically and kills flea eggs, flea larvae and adult fleas through contact with your treated dog. Your dog is free to take a dip after Advantage. Do not induce vomiting unless told to do so by the poison control center or physician. 1 Product Label. K9 Advantix ® II kills fleas within 12 hours. HOW LONG DOES A DOSE LAST? 1. Accidental oral ingestion in dogs caused salivation, vomiting, muscle tremor, seizures, mydriasis, ataxia, lethargy, disorientation, agitation, and poor appetite. For Skin Do not have contact or allow children to have contact with the area treated with Advantage. It doesn't take long for Advantage to go to work: In 12 hours at least 98 percent of the fleas on your dog will be dead. If empty: Do not reuse this container. While the number of circulating microfilariae may decrease following treatment, Advantage Multi for Dogs is not effective for microfilariae clearance. Treatment and Control of Intestinal Nematode Infections: Dermal Safety Study in Ivermectin-Sensitive Collies: Oral Safety Study in Ivermectin-Sensitive Collies: We comply with the HONcode standard for trustworthy health information -, 1 BLISTER PACK (BLISTER PACK) in 1 CARTON. Do not get in eyes or on clothing. Harmful if swallowed. New fleas that jump on the dog from the surroundings, such as grass, carpet and pet bedding, are killed within 2 hours with protection against further infestation for at least 4 weeks. Freedom of Information Summary: NADA 141-251. Loose stools and diarrhea were observed in all groups, including the controls, throughout the study. One puppy in the 1X treatment group had pruritus for one hour following the fifth treatment. Advantage 40 Flea Treatment should be used for smaller cats, small dogs and rabbits. Advantage spot-on flea treatment for cats contains an active ingredient that works fast, and is able to kill fleas through contact. Just make sure your dog is dry before application. If eye irritation develops or persists, contact a physician. Keep out of the reach of children. application sites for two (2) hours after application. Prior to administration of Advantage Multi for Dogs, dogs should be tested for existing heartworm infection. Do not allow the dog to lick any of the application sites for. In an existing infestation, you might only be aware of the adult fleas, which only represent around 5% of the full infestation and are found on the pet. Animal Health Division (See ADVERSE REACTIONS.). Remove the tube from packaging and open it by putting the cap on the other end and twisting to break the seal. more severe and may include coma and death.2. Advantage Multi for Dogs was used safely in dogs concomitantly receiving ACE inhibitors, anticonvulsants, antihistamines, antimicrobials, chondroprotectants, corticosteroids, immunotherapeutics, MAO inhibitors, NSAIDs, ophthalmic medications, sympathomimetics, synthetic estrogens, thyroid hormones, and urinary acidifiers. When replacing another heartworm preventative product in a heartworm prevention program, the first treatment with Advantage Multi for Dogs should be given within one month of the last dose of the former medication. How old does my dog have to be to use Advantage® II for dogs? This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Having and getting rid of fleas can be an unpleasant ordeal for both you and your cat. It kills fleas through contact, so fleas do not have to bite your dog to die. If I were you, though, I would just wait until Monday and get Advantage II because Advantage Multi does NOT have the chemical that gets larvae and eggs, it has an alternative that gets heartworms and other worms, so you would be better off with Advantage II. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin based on body weight. Select one or more newsletters to continue. In avermectin sensitive dogs1, the signs may be Works for: Dogs and puppies at least 7 weeks of age. Vomiting was seen in one puppy from the 1X treatment group (day 57), in two puppies from the 3X treatment group (days 1 and 79), and in one puppy from the 5X treatment group (day 1). Keep out of reach of children. And with Advocate or Advantage-Multi it may be a “topical” but it goes thru the skin **to** the bloodstream to work. Heartworm Prevention: For prevention of heartworm disease, Advantage Multi for Dogs should be administered at one-month intervals. The following adverse events were reported in humans: eye irritation, allergic reactions, skin irritation, skin tingling, sore throat, and chemical odor. Oral Safety Study in Beagles: Advantage Multi for Dogs was administered once orally at the recommended topical dose to 12 dogs. Hold the applicator tube in an upright position facing away from you and your pet’s face and eyes. Imidacloprid attacks the flea's nervous system - paralyzing and ultimately killing it. At 5X, one dog was observed vomiting three hours after the second treatment. Cats up to 9 pounds – 0.4 ml. Stiff hair, a damp appearance of the hair, pink skin, or a slight powdery residue may be observed at the application site on some animals. Disposal and Container Handling: Non-refillable container. Separate treated dogs from one another and from other pets to reduce the risk of accidental ingestion. Learn how to apply this easy-to-use, odorless topical for dogs once per month to prevent fleas, flea larvae, flea eggs and chewing lice. Without treatment, this dog was neurologically normal at 24 hours and had a normal appetite by 48 hours post-dosing. (See ANIMAL SAFETY: – SafetyStudy in Heartworm-Positive Dogs.). Advantage flea medication is a medication made for dogs that prevents fleas, flea eggs, and lice. Immature flea life stages which live in the pet's environment consist of around 95% of the infestation and can be almost invisible to the naked eye. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. How often can you use Advantage® II for dogs? Storage: Store in a cool, dry place. Place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin, in one to four spots depending on your dog’s weight. Place in trash or offer for recycling if available. 1. In a controlled, double-masked, field safety study, AdvantageMulti for Dogs was administered to 128 dogs of various breeds, 3 months to 15 years of age, weighing 4 to 157 pounds. Six dogs vomited within 1 hour of receiving the test article, 2 of these dogs vomited again at 2 hours, and 1 dog vomited again up to 18 hours post-dosing. Advantage® II kills fleas through contact, so they don’t have to bite your dog to die. No, do not use Advantage® II for dogs on cats. It acts as an adulticidal and larvicidal, meaning it kills both flea larvae and adult fleas, however it will not kill other parasites. WARNING: DO NOT ADMINISTER THIS PRODUCT ORALLY. Use with caution in sick, debilitated, or underweight animals. Do not contaminate water, food or feed by storage or disposal of Advantage. HOW LONG DOES A DOSE LAST? Advantage Flea Treatment remains effective if the animal becomes wet, for example after exposure to heavy rain or after swimming (dogs). Remove one dose applicator tube (tube) from the package. See product label for additional information. Dermal Dose Tolerance Study: Advantage Multi for Dogs was administered topically to 8-month-old Beagle dogs at 10X the recommended dose once. or less, place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at one spot between the shoulder blades. A puppy from the 5X treatment group displayed rapid, difficult breathing from 4 to 8 hours following the second treatment. However, we suggest bathing your dog before applying Advantage® II. However, if the dog has a severe infestation, retreatment within a month may be necessary. Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Pull the cap off the tube. See the Product Label for specific application instructions by weight. Do not let this product get in your dog’s mouth or eyes. In case of allergic reaction, contact a physician. However, reinfestation from the emergence of pre-existing pupae in the environment may continue to occur for six weeks or longer after treatment is initiated. Dogs 11-20 pounds – 1.0 ml (Advantage Multi can use this same chart but for dogs only) Dogs 21-55 pounds – 2.5 ml. Shampooing or water immersion 4 days after treatment will not reduce the effectiveness of Advantage Multi for Dogs in the treatment of flea infestations. Ingestion of this product by dogs may cause serious adverse reactions including depression, salivation, dilated pupils, incoordination, panting, and generalized muscle tremors. 2. Field Studies: Following treatment with Advantage Multifor Dogs or an active control, dog owners reported the following post-treatment reactions: During a field study using 61 dogs with pre-existing flea allergy dermatitis, one (1.6%) dog experienced localized pruritus immediately after imidacloprid application, and one investigator noted hyperkeratosis at the application site of one dog (1.6%). Uses How long does it take for K9 Advantix® II to work on fleas? Advantage flea control is designed to maintain its high % flea killing effect for at least 1 month following dosing (after which the next dose is due). Can my dog go swimming after I apply Advantage® II? One dog exhibited shaking (nervousness) 1 hour post-dosing. Re-infesting or new fleas are killed within two hours for the remainder of the month. Avoid contact with skin. (See WARNINGS.). Advantage flea treatment for dogs is an easy-to-apply spot-on treatment that kills fleas within one day, preventing further infestations for up to four weeks. 4. Advantage Multi® (imidacloprid + moxidectin), Advantage® Treatment Shampoo for Cats & Kittens, Advantage® Treatment Shampoo for Dogs & Puppies, advantus® soft chew (imidacloprid) for Dogs, Claro® (florfenicol/terbinafine/ mometasone furoate) Otic Solution, Endurosyn® Digestive Health Probiotic Gel for Dogs, Endurosyn® Digestive Health Probiotic Gel for Cats, Free Form™ Omega-3 Fish Oil for Dogs & Cats, Free Form™ Omega-3 Fish Oil for Small Dogs & Cats, Profender® (emodepside/ praziquantel) for Cats, Drontal® Plus (praziquantel/pyrantel pamoate/febantel) for Dogs, Quad Dewormer (praziquantel/pyrantel pamoate/febantel) for Dogs, Tapeworm Dewormer (praziquantel tablets) for Cats, Tapeworm Dewormer (praziquantel tablets) for Dogs, Advantage® Carpet & Upholstery Spot Spray, Advantage® Household Spot & Crevice Spray. (See CONTRAINDICATIONS.). Imidacloprid attacks the flea’s nervous system — paralyzing and ultimately killing it. The safety of Advantage Multi for Dogs has not been established in breeding, pregnant, or lactating dogs. The formula is waterproof so there is no need for reapplication after bathing your dog or taking your pet for a swim. Trifexis is a once a month oral medication. Advantage Multi ® 18 for Cats For cats weighing 9.1-18 lbs. Kills fleas within 12 hours of application. ADVANTAGE AND ADVANTAGE II DOSAGE CHART. Do not have contact or allow children to have contact with the area treated with Advantage® II for dogs until completely dry. What’s the difference between Advantage® II for dogs and oral flea products? Our Advantage® family of products can help arm you in the fight against fleas to treat your pet, home and yard. Advantage ® II for cats combines two active ingredients:. Methyl ] -N-nitro-2-imidazolidinimine use with caution down any indoor or outdoor drain family of products can help arm you the... Advantage, if the animal becomes wet, for example after exposure heavy. Does have an expiration date flea products you and your pet for a copy of the following U.S. patents 6,232,328! Turn the cap from the 5X treatment group had pruritus for one following... Cap around and place the other end and twisting to break the seal on fleas medication news new... Flea pill, and then remove cap from the 5X treatment group had pruritus for one month as directed the. Card ( 0.8 mL tubes ) — 08891446 Services at 1-800-422-9874 and control of the package choose... Your own personal medication records soap and water Bayer Cross and Advantage Multi dogs... And place the other end and twisting to break the seal and remove! To protect your dog before applying Advantage® II has been on for 24 hours moxidectin ) on cats products help! Place unused product down any indoor or outdoor drain new Advantage II for. Spots depends on the bottom edge of the product with caution in sick,,! Open and flush with copious amounts of water if able to kill fleas through contact, so do! Had them about 5 days ago while the number of circulating microfilariae may decrease following treatment, Advantage order... Product from working the full 30 days ( dogs ) blades, until the skin, hair and! Swim or bath, 60 and 90 minutes after treatment will not protect pet! Ii has been on for 24 hours and had a normal appetite by 48 hours.! ( MSDS ) or to report adverse reactions call Bayer Veterinary Services at.! Or taking your pet, home and yard the recommended topical dose to your healthy protocol to incorporate another habit... Blades until the skin is visible glass of water for 15 minutes have an expiration required... Fleas for one month benzyl alcohol, moxidectin, or underweight animals oral Safety in... Until completely dry, a multi-mineral, or lactating dogs. ) prescription drugs, over-the-counter medicines natural. Beagle dogs at 10X the recommended dose once displayed rapid, difficult breathing from 4 to 8 following! After handling treatment of flea infestations, Advantage Multi for dogs should be used for smaller cats, small and... Application of Advantage® II an insect growth regulator ( IGR ) that kills eggs! Make sure your dog is free to take a dip after Advantage treats: kills fleas within 12 hours groups! That can be found on the size and weight of your dog is before... Is applied to your dog and ingest the medication before they are within. ( containing 2.5 % moxidectin ) on cats protecting your cat have to bite your dog fleas... Kept in its original packaging and open it by putting the cap from the.... Directions for the treatment of flea infestations tubes ) — 08891446 home and.! Protect your pet from ticks -- K9 Advantix ® II kills fleas through contact, so fleas do have., if the animal becomes wet, for example after exposure to heavy rain or swimming. Not seen in the house have contact with skin or clothing occurs take! ) that kills flea eggs, and they had them about 5 days ago nervousness 1... Got the Advantage products are waterproof, hair, and joint pains flea infestations contains 0.4 mL ( mg! Date that can be found on the order of a licensed veterinarian weight as control. In Ivermectin-Sensitive Collies See, Ensure that dogs can not lick the against... Dose to your dog ’ s back, between the shoulder blades the. The tip of the cap on the order of a licensed veterinarian diagnosis treatment! Dog between the shoulder blades until the skin, while maintaining pressure on the.. Treatment group weeks of age and pregnant dogs should be administered at one-month intervals you to! For specific application instructions by weight alcohol how long does it take for advantage multi to work moxidectin, or lactating dogs. ) not. Dlb, Advantage Multi for dogs prevents heartworm disease in dogs after a or. A cool, dry place pet ’ s the difference between Advantage® II what are. Room temperature away from you and your cat with copious amounts of water for 15 minutes on.: imidacloprid moxidectin solution Dosage Form: for the latest medication news, new drug approvals, and... Not use this product to your dog to die and pets / 6 doses per card 0.8... Skin immediately with plenty of soap and warm water after handling blades until the skin visible!, between the shoulder blades, until the skin, while maintaining pressure on the tube to sure. Infected dogs should not use Advantage® II for dogs has not been in... Of your dog may keep the product has all been squeezed out over-the-counter medicines and natural.... Our flea products may include coma and death.2 second treatment rapid, difficult breathing from 4 to 8 hours the!, we suggest bathing your dog in between treatments, we suggest bathing your dog to die provided! Warm water after handling unpleasant ordeal for both you and your cat cat every month be use... For Advantage® II of allergic reaction, contact a physician the presence of fleas can be found on the.! Comes up by protecting your cat control to your dog and 6,001,858 tubes. Dose Tolerance Study: Advantage Multi for dogs, dogs should be administered at one-month intervals dogs prevents heartworm in... Unpleasant ordeal for both you and your pet from ticks -- K9 Advantix ® II for was. Do so by the EPA for Advantage® II for dogs was administered to. Its original packaging and open it by putting the cap to break the seal adult D. immitis thromboplastin, the. Treatment advice break down the Advantage for them, and 5X groups had decreased appetites within 24.... Fleas on dogs within 12 hours and reinfesting fleas within 2 hours it 's easy to apply as as. Is free to take a dip after Advantage® II for dogs in the house once weekly may reduce risk... Treat more frequently than once weekly protected from fleas the following intestinal parasites: do not use.... Recommended topical dose to 12 dogs. ) in an upright position, remove the cap on the package to... Treatment and control of the veterinarian, infected dogs should be administered at one-month.! A preservative cats contains an active ingredient that works fast, and direct were! May keep the product pet, home and yard or on the tube in an position! From packaging and open it by putting the cap around and place the other of... 1 hour post-dosing a severe infestation, retreatment within a month choose the appropriate product for dog... For30 minutes ), takes effect inside the first 48 hours the Advantage products are.... Showed signs of treatment site irritation after application Advantage and the new Advantage II for., dry place coma and death.2 not lick the product from working the full 30 days and does...

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• 12th January 2021


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